Cell proliferation, enamel gene expression, and accumulation of enamel-forming proteins were observed, with statistically significant increases for the RGDS-displaying PA compared with control PAs. Strain and kinematics of deformation. The mechanism of the transfer of energy by thermal radiation; radiant properties of materials, energy transfer prediction methods and solar energy topics. Incorporation of stress and deformation analyses and applicable material failure theories literatively until all design needs and constraints are satisfied. Direct transplantation of embryonic stem cells or endothelial progenitor cells to ischemic tissue typically results in low cell viability, resulting in the need for a biocompatible and injectable delivery matrix to support cell proliferation and differentiation. Introduction to the design process.
Please wait while we load your content In vivo bioluminescent imaging of transplanted bone marrow mononuclear cells BMNCs in mice 4 days after subcutaneous injection. The formation of therapeutic films by solution casting or electrospinning of naturally derived silk fibroin and by multilayer complexation of charged polypeptides has been studied for over two decades [ 82 – 85 ]. Properties of feedback control systems, mathematical models of basic components, state-variable models of feedback systems, design specifications of control systems, time-domain analysis, stability, stability robustness, transform analysis, frequency domain techniques, root-locus, design of single-input-single-output systems and compensation techniques for engineering systems. Regeneration of tunica media with anisotropic architecture still remains a challenging issue for vascular tissue engineering TE. Teamwork, leadership and presentation skills emphasized. Injection of these conditioned HBPA gels following coronary artery ligation resulted in preservation of hemodynamic function in a mouse ischemia-reperfusion model of acute myocardial infarction and also promoted extensive revascularization in chronic rat ischemic hind limb models Figure 7.
Analysis of stiffness and deflection of straight and curved beams, columns, and links. Robotic force control and its applications in industry.
Peptide Self-Assembly for Crafting Functional Biological Materials
Special projects and independent study in mechanical or aerospace engineering. In-depth, systematic studies of combined soluble and insoluble signals will greatly enhance the capabilities and biological understanding of biomaterials in regenerative medicine.
Using a rat femoral defect model, PA gel was added into the critically sized defect while a titanium plate was used to secure the defect space. In meda studies, we applied IKVAV-presenting PA gels to spinal cord injury sites in a mouse model to inhibit glial scar formation, which is a significant factor preventing axonal regeneration [ 57 ].
Setup and solution of equations which govern mechanical engineering systems. Advanced convective heat transfer in laminar and turbulent flows over external surfaces and inside channels. In an effort to add an additional aspect of surface topology to bone regeneration with PA gels, our group investigated micropatterned PA materials as substrates for osteogenesis [ 51 ].
Mechanical & Aerospace Engineering (MAE)
Admission to MAE professional school. Design of power transmission systems, including belts, chains and gears. Osteogenesis of MT3T3-E1 cells in 2D culture on top of these gels was observed, with some cell migration into the scaffold when the osteopontin-derived peptide sequence was used.
Consideration of static and fatigue failure theories for various types of engineering materials.
Stability is a fundamental problem in solid mechanics, which is crucial to the safety of structures against collapse. Graduate Standing or consent of instructor. Computer applications in solid mechanics, heat transfer and fluid mechanics.
The in vivo injection of peptide gels containing neonatal cardiomyocytes and embryonic stem cells into the myocardium further showed the ability of these gels to recruit and promote survival of endothelial and smooth muscle cells for vascularization [ 64 ]. Author information Copyright and License information Disclaimer. Such studies suggest the potential for peptide-based matrices bearing adhesion-promoting epitopes to overcome limitations facing cell-based therapies for ischemic injury.
For reproduction of material from PCCP: B New bone formation is observed adjacent to and into the PA—Ti hybrid. Also, biomaterial issues related to drug delivery and tissue engineering will be discussed.
Self-assembling peptide scaffolds promote enamel remineralization. Basic principles governing the micro-mechanics of a lamina, and the macro-mechanics of a laminate are discussed in detail. Offered for variable credit, credit hours, maximum of 30 credit hours.
Self-assembly of peptide amphiphiles: A versatile scaffold for the preparation of self-assembling materials. Search articles by author Jenny Brinkmann. Considerations of accuracy, uncertainty and repeatability.
Mechanical & Aerospace Engineering (MAE) < Oklahoma State University
This may take some time to load. Extensive neurite outgrowth and active synapse formation on self-assembling peptide scaffolds. Regeneration of the cavernous nerve by Sonic hedgehog using aligned peptide amphiphile nanofibers. Design and analysis of feedback control system using frequency-domain and state-space methods.
Peptide Self-Assembly for Crafting Functional Biological Materials
In this review, we highlight recent advances in peptide-based gels and membranes, including work from our group and others. Thermal engineering of refrigeration and heat pump systems, vapor compression systems, absorption refrigeration cycles, cryogenics, compressors, heat exchangers, flow control devices, laboratory simulators and measurements, socio-economics and environmental impact of systems and refrigerants.
Endothelial cells and myocardial cells have also been shown to survive well within gels assembled from ionic self-complementary peptides in vitro [ 63 ]. Application of advanced experimental mechanics techniques to investigate and characterize response of solid materials. A student studying for a master’s degree who elects to write a thesis must enroll in this course. State-of-the-art instrumentation, diagnostic, and computerized data acquisition equipment and techniques applied to experiments including application of low speed wind tunnel testing techniques, rocket propulsion and control-jet experiments, fundamentals of supersonic nozzles, and flight test evaluation meia performance, stability, 32293, and handling qualities of a propeller-driven airplane.
For reproduction of material from NJC: Analysis of nonlinear caast, classical analysis of continuous systems and numerical methods. Atomistic molecular dynamics simulations of peptide amphiphile self-assembly into cylindrical nanofibers. Introduction to vector fields and Lie algebra: Use of common machine tools to build machine components. Application and solution of the governing equations to describe the steady state or transient behavior of dynamics, mechanics and circuit problems.
Micropatterning of bioactive self-assembling gels. This course will provide students with the basic knowledge necessary to conduct biomechanics investigations, design implants and prosthetics, and interact with other medical professionals. We further demonstrated the benefits of HBPA nanofiber gels in cardiovascular therapy by demonstrating their ability to bind paracrine factors from hypoxic conditioned stem cell media[ 74 ].
Approximate methods in discrete-time representation. Specifically, we discuss the application of peptide-based materials in the regeneration of bone and enamel, cartilage, and the central nervous system, as well as the transplantation of islets, wound-healing, cardiovascular therapies, and treatment of erectile dysfunction after prostatectomy. The formation of therapeutic films by solution casting or electrospinning of naturally derived silk fibroin and by multilayer complexation of charged polypeptides has been studied for over two decades 2393 82 – 85 ].
Notions of energy, entropy, equilibrium, macrostates, and microstates and their relation to material processes and properties.
Maximum control of cell growth and behavior in vivo will likely be enabled through the use of multiple signaling epitopes in combination with soluble factor release with an optimized temporal profile.
Hierarchically structured peptide amphiphile-biopolymer membranes are also discussed.