We found high detection rates in maternal blood for a number of chemicals but limited detection in cord blood. Effects of environmental exposures on the cardiovascular system: Developmental origins of adult diseases and neurotoxicity: Albumin measurements can be used as a surrogate for plasma volume expansion in pregnancy. During pregnancy and lactation, body burdens of chemicals may change due to the significant physiological changes that occur. Contaminants, diet, plasma fatty acids and smoking in Greenland

Multiple chemicals were detectable in the serum of the pregnant women in our study cohort, however the concentrations were much lower than those seen in other studies. We would like to sincerely thank the participants of the MIREC study for their contributions to the study. The Bonferroni-adjusted confidence intervals are a very conservative method – means a significant negative association e. Note that the highest detection limit is presented in tables when several detection limits were noted. Traditionally research has focused on single chemicals in the exposure assessment; however, there is growing recognition of the need to better assess the risk of mixtures and to understand the cumulative effects of multiple exposures and stressors [ 71 ]. Int J Hyg Environ Health. In cord plasma PFOA had the highest detection rate. Determinants of serum concentrations of 1,1-dichloro-2,2-bis p-chlorophenyl ethylene and polychlorinated biphenyls among French women in the CECILE study.

The mean maternal age was The PFASs were moderately correlated with each other. It may also reflect a difference in recruitment methods over time e. This result is supported by the work by Woodruff et al.

However in cord plasma, PFOA had the highest detection rate. Generalized, Linear, and Mixed Models. Contaminants cis-nonachlor, Mirex, Parlar, and Parlar were not detected in the cord blood. They are used in a wide variety of products including non-stick cookware, breathable all weather clothing, wiper blades, wire and cable insulation, fire retardant foams, lubricants, paper coatings, pharmaceuticals, and nail polish [ 2 ].


Lipid adjusted models included total lipids of each sample as a covariate in the linear model with the potential predictor of interest.

These changes may have an impact on absorption, distribution, metabolism and excretion of environmental contaminants, which has potentially serious implications for developmental exposures of the fetus. Received Jul 17; Accepted Apr Plasma volume expansion in pregnancy: Generally, as the parity increases, the contaminant concentrations tended to mandu.

Association between perfluoroalkyl substances and thyroid stimulating hormone among pregnant women: Mandy FisherTye E.

Methods The MIREC Study is a national-level pregnancy cohort of approximately women recruited from 10 cities across Canada and has been previously described [ 37 msndy. The questionnaires collected information such as sociodemographics, current and previous pregnancies, diet, smoking and lifestyle. Foreign-born participants had significantly higher concentrations of organochlorinated pesticides and PCBs.

Population surveys in Greenland Similar to other studies, we found parity, maternal age, income, education, smoking filj, pre-pregnancy BMI and fish consumption to be significant predictors for most chemicals.

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Comput Methods Programs Biomed. Please review our privacy policy. Table 9 Hypothesis testing summary. Most contaminants were found to be higher in non-smokers and former smokers than current smokers, except for PFOS. During pregnancy and lactation, body burdens of chemicals may change due to the significant physiological changes that occur.

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These chemicals were chosen based on evidence of potential reproductive toxicity, and valid laboratory methods available for biomarkers. United National Environment Program; Contaminant residue levels were higher among those mothers who did not fast.

The intra-day precision repeatability and the inter-day precision reproducibility of the method were respectively between 1. However no association was observed if they microwaved with non-stick cooking vessels. Research Ethics Board approval was obtained from all participating sites and Health Canada.

Acknowledgements We would like to sincerely thank the participants of the MIREC study for their contributions fiilm the study. For household income we saw significant differences with and without lipid adjustment.


Women who gave informed consented scheduled visits in each trimester, at delivery and in the postpartum period up to weeks. Studies have found PBDEs in fish, dairy products and eggs [ 1617 ]. A Trinational Biomonitoring study [ 45 ] also showed consistently higher concentrations in Canadian immigrants than in Canadian born participants. Some POP exposures during fetal developmental have been linked with thyroid hormone disruption [ 2327 — 29 ], adverse birth outcomes [ 30 — 32 ], poorer respiratory health [ 33 ], obesity [ 34 ], and neurotoxicity ooostdam 3536 ].

The Greenwood estimate filj variance was used for determination of Kaplan-Meier confidence intervals. Author information Article notes Copyright and License information Disclaimer. POP compounds were extracted with hexane from the aqueous matrix using a liquid-liquid extraction in the presence of a saturated ammonium sulfate solution for salting out. Accessed 12 Apr, Note that these ratios are only presented for pairs of maternal and cord plasma samples that are both madny the LOD.

Biomarker measurements in a coastal fish-eating population environmentally exposed to organochlorines. A subset of chemicals was also chosen based on that measured in Cycle ooetdam — of the Canadian Health Measures Survey [ 2 ] so that comparisons could be made to the general population biomonitoring data, given that measurements were made by the same laboratory.

Background Persistent organic pollutants POPsincluding organochlorine pesticides OCsindustrial chemicals and their by-products are chemicals that persist in the environment and tend to bioaccumulate, possess toxic properties, and resist degradation [ 1 ].